Drug Induced Liver Injury (DILI)

Drug Induced Liver Injury (DILI) Photo

Drugs are an important cause of liver damage. More than nine hundred medications, toxins, and herbs have been reported to cause liver damage, and drugs represent twenty to forty percent of all cases of fulminant hepatic failure. Roughly seventy five percent of the idiosyncratic drug reactions result in liver transplantation or death. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. Knowledge of the commonly implicated agents and a high index of suspicion are essential in diagnosis.

  • Best Practices in Clinical Drug Development Moderators
  • Evaluating DILI Signals in Clinical Trials to Inform Benefits, Risks Moderators
  • New Tools for Detection and Assessment of DILI Moderators
  • Consortia for Best Practices to Reduce DILI

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