Liver growth and repair

Liver growth and repair Photo

The liver is the main instinctive organ that has the astounding ability to recover. The liver can recover after either surgical removal or after chemical injury. It is known that as little as 25% of the original liver mass can recover back to its full size. The process of recovery in mammals is essentially compensatory development in light of the fact that lone the mass of the liver is replaced, not the shape. However, in lower species, for example, fish, both liver size and shape can be replaced. Liver recovery includes replication of the liver cells, mainly hepatocytes, followed by other cells such as biliary epithelial cells and sinusoidal endothelial cells. When cell proliferation is finished, the recently isolated cells experience rebuilding, angiogenesis and renewal of extracellular matrix to finish the recovery procedure. Strikingly, much of the time, liver function is only partially affected during liver recovery. While certain particular functions, for example, drug metabolism decrease, many other primary functions such as albumin and bile production are not substantially influenced.

  • Molecular and cellular analysis of liver growth
  • Growth factors
  • Signalling events
  • Biology of the extracellular matrix and non-parenchymal cells
  • Human liver growth and clinical applications

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