Dr. Yu-Jui Yvonne Wan research program has been focusing on the role of retinoic acid receptors and other nuclear receptors in regulating liver health and diseases. The liver is the major retinoic acid target organ.Retinoic acid’s precursor (vitamin A) is stored in the liver, where the highest level of retinol binding protein and receptor (RXR?) is produced. Using the liver-specific RXR?-deficient mouse model that his laboratory has developed, he identified the novel role of retinoid-mediated pathways in lipid, carbohydrate, xenobiotic, and amino acid metabolism and homeostasis in health and various diseased states. In addition, he discovered other novel roles of hepatic RXR? in alcohol detoxification, steatosis, steatohepatitis, inflammation, as well as liver regeneration. These findings unequivocally established the functional significance of hepatic RXR? in regulating liver physiology and pathology.
Cellular and molecular biology of the liver, Liver Cancer, Liver Immunology
Dr SM Wasim Jafri is a Pakistani Gastroenterologist. He fills in as a professor of medicine and head of the gastroenterology section at the Aga Khan University, Karachi, Pakistan. He obtained his high school education at the Don Bosco High School, Lahore. His family moved from Lahore to Karachi where he studied at the D. J. Science College. He later Completed his medicine at the Dow Medical College, Karachi and obtained his MBBS degree from the University of Karachi. Dr Jafri received training in general medicine and gastroenterology between 1978 and 1984 from England. He is one of the leading gastroenterologists in his region. He has published more than 70 publications in peer reviewed journals. His main areas of interest are chronic liver diseases from hepatitis B and C. He is the president of Pakistan Society for the Study of Liver Diseases (PSSLD).
Gastroenterology, Clinical Trials, Pharmacy & Therapeutics, Liver Diseases, Endoscopy, Hepatology Antibiotic Resistance Mechanism